Author

B. L. Prosser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. Heffler· 2 shared A. Abbas· 1 shared A. D. Thompson· 1 shared A. I. Bogush· 1 shared A. Malhotra· 1 shared A. S. Helms· 1 shared A. Salomon· 1 shared B. Geertz· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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2 shared papersCell Biology

J. Heffler

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Microtubule forces drive nuclear damage in LMNA cardiomyopathy

D. Amiad Pavlov, J. Heffler, C. S. Corredera, M. Dehghany, K. M. Shen, N. Zuela-Sopilniak, R. Randell, K. Uchida, R. Jain, V. Shenoy, J. Lammerding, B. L. Prosser

This study shows that microtubule forces, not the LINC complex, drive nuclear damage in LMNA cardiomyopathy and that disrupting microtubules can rescue cardiac function.

bioRxiv · Feb 10, 2024 · PreprintCell Biology

Chronic activation of tubulin tyrosination in HCM mice and human iPSC-engineered heart tissues improves heart function

N. Pietsch, C. Y. Chen, S. Kupsch, L. Bacmeister, B. Geertz, M. Herera-Rivero, H. Voss, E. Krämer, I. Braren, D. Westermann, H. Schlüter, G. Mearini, S. Schlossarek, J. van der Velden, M. A. Caporizzo, , L. Carrier

bioRxiv · May 25, 2023Physiology

An unbiased screen identified the Hsp70-BAG3 complex as a regulator of myosin binding protein C3 stability.

A. D. Thompson, M. J. Wagner, J. Rodriguez, A. Malhotra, S. Vander Roest, U. Lilienthal, H. Shao, J. Yob, B. L. Prosser, A. S. Helms, J. E. Gestwicki, D. E. Ginsburg, S. M. Day

A high-throughput compound screen identified JG98 and parthenolide as reducing MyBP-C levels, revealing the Hsp70-BAG3 complex as a regulator of MyBP-C stability in HCM.

bioRxiv · Oct 8, 2022Cell Biology

Desmin intermediate filaments and tubulin detyrosination stabilize growing microtubules in the cardiomyocyte

A. Salomon, S. A. Phyo, N. Okami, J. Heffler, P. Robison, A. I. Bogush, B. L. Prosser

This study shows that desmin and detyrosination stabilize microtubules at the Z-disk in cardiomyocytes, enhancing cytoskeletal stiffness and contractile function.

bioRxiv · May 26, 2021Cell Biology

Mechanosensing by the lamina protects against nuclear rupture, DNA damage, and cell cycle arrest

S. Cho, M. Vashisth, A. Abbas, S. Majkut, K. Vogel, Y. Xia, I. L. Ivanovska, J. Irianto, M. Tewari, K. Zhu, E. D. Tichy, F. Mourkioti, H.-Y. Tang, R. Greenberg, B. L. Prosser, D. E. Discher

The paper shows that lamin-A stabilizes the genome by protecting against nuclear rupture, DNA damage, and cell cycle arrest under mechanical stress.

bioRxiv · Mar 20, 2019Cell Biology