Author

A. Descoteaux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

G. Arango Duque· 3 shared C. Matte· 2 shared M. Jaramillo· 2 shared A. Fabie· 1 shared A. Zimmermann· 1 shared A.-M. Berthiaume· 1 shared C. Meneses· 1 shared I. V. Coutinho-Abreu· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersImmunology

G. Arango Duque

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Revisiting Leishmania GP63 host cell targets reveals a limited spectrum of substrates

M.-M. Guay-Vincent, C. Matte, A.-M. Berthiaume, M. Olivier, M. Jaramillo, A. Descoteaux

This study re-examines GP63 substrates in Leishmania-infected macrophages by inhibiting GP63 activity during lysate preparation, revealing a limited set of genuine substrates.

bioRxiv · Jun 6, 2022Microbiology

Leishmania donovani metacyclic promastigotes impair phagosome properties in inflammatory monocytes

C. Matte, G. Arango Duque, A. Descoteaux

This study shows Leishmania donovani metacyclic promastigotes impair phagosome function in inflammatory monocytes by inhibiting superoxide production and acidification.

bioRxiv · Jan 7, 2021Immunology

Sec22b regulates inflammatory responses by controlling the nuclear translocation of NF-κB

G. Arango Duque, R. Dion, A. Fabie, J. Descoteaux, S. Stäger, A. Descoteaux

This study shows Sec22b controls NF-κB nuclear translocation and inflammatory mediator release by regulating phagosome maturation and cytokine/NO secretion in dendritic cells.

bioRxiv · Sep 20, 2020Cell Biology

Binding of Leishmania infantum LPG to the midgut is not sufficient to define vector competence in Lutzomyia longipalpis sand flies

I. V. Coutinho-Abreu, J. Oristian, W. de Castro, T. R. Wilson, C. Meneses, R. P. Soares, V. M. Borges, A. Descoteaux, S. Kamhawi, J. Valenzuela

This study shows that Leishmania infantum LPG is not necessary for midgut retention in permissive sand flies but protects certain strains from blood digestion toxins.

bioRxiv · Jun 10, 2020Microbiology

Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts

V. Chaparro, L.-P. Leroux, L. Masvidal, J. Lorent, T. E. Graber, A. Zimmermann, G. Arango Duque, A. Descoteaux, T. Alain, O. Larsson, M. Jaramillo

This study identifies mTOR- and eIF4A-sensitive immune-related transcripts in Leishmania donovani-infected macrophages, showing their role in modulating mRNA metabolism and immune responses.

bioRxiv · Dec 20, 2019Immunology