Author

J. Oristian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1

Frequent Co-Authors

C. Meneses· 4 shared S. Kamhawi· 4 shared G. Matlashewski· 3 shared G. Volpedo· 3 shared J. G. Valenzuela· 3 shared N. Ismail· 3 shared R. DEY· 3 shared S. Gannavaram· 3 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

C. Meneses

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Centrin-deficient Leishmania mexicana confers protection against Old World visceral leishmaniasis

S. Karmakar, G. Volpedo, W.-W. Zhang, P. Lypaczewski, N. Ismail, L. F. Oliveira, J. Oristian, C. Meneses, S. Gannavaram, S. Kamhawi, S. Hamano, J. G. Valenzuela, R. DEY, A. R. Satoskar, G. Matlashewski, H. Nakhasi

This study shows that centrin-deficient L. mexicana parasites protect against Old World visceral leishmaniasis in a hamster model by reducing parasite burden and altering cytokine responses.

bioRxiv · Jun 27, 2022Immunology

Light chain 2 is a Tctex-type related axonemal dynein light chain that regulates directional ciliary motility in Trypanosoma brucei

S. Godar, J. Oristian, V. Hinsch, K. Wentworth, E. Lopez, P. Amlashi, G. Enverso, S. Markley, J. D. Alper

This study identifies TbLC2, a Tctex-type dynein light chain in Trypanosoma brucei, and shows it regulates ciliary beating direction and motility.

bioRxiv · Sep 29, 2021Biophysics

Preclinical validation of a second generation leishmanization vaccine against vector transmitted fatal visceral leishmaniasis

H. L. Nakhasi, R. DEY, S. Gannavaram, S. Karmakar, P. Bhattacharya, N. Ismail, A. Satoskar, G. Volpedo, L. F. Oliveira, J. Oristian, C. Meneses, J. G. Valenzuela, S. Kamhawi, W. W. Zhang, G. Matlashewski, , K. Pandey

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

bioRxiv · Nov 18, 2020Immunology

Binding of Leishmania infantum LPG to the midgut is not sufficient to define vector competence in Lutzomyia longipalpis sand flies

I. V. Coutinho-Abreu, J. Oristian, W. de Castro, T. R. Wilson, C. Meneses, R. P. Soares, V. M. Borges, A. Descoteaux, S. Kamhawi, J. Valenzuela

This study shows that Leishmania infantum LPG is not necessary for midgut retention in permissive sand flies but protects certain strains from blood digestion toxins.

bioRxiv · Jun 10, 2020Microbiology

A Second Generation Leishmanization Vaccine with a Markerless Attenuated Leishmania major Strain using CRISPR gene editing

W. W. Zhang, S. Karmakar, S. Gannavaram, R. Dey, P. Lypaczewski, N. Ismail, A. Siddiqui, V. Simonyan, F. Oliveira, I. V. Coutinho-Abreu, T. DeSouza-Vieira, C. Meneses, J. Oristian, T. D. Serfim, A. Musa, , H. L. Nakhasi

This paper describes a CRISPR-edited Leishmania major strain for a second-generation leishmanization vaccine that is marker-free and safe, showing protection in mice comparable to traditional leishmanization.

bioRxiv · May 4, 2020Microbiology