Author

T. Alain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Microbiology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2

Frequent Co-Authors

S. M. Jafarnejad· 3 shared A. Garzia· 2 shared H.-D. Hoang· 2 shared J. Luo· 2 shared J.-H. Choi· 2 shared N. Sonenberg· 2 shared P. Naeli· 2 shared T. Duchaine· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

S. M. Jafarnejad

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Ribosome Quality Control Mechanism Mitigates the Cytotoxic Impacts of Ribosome Collisions Induced by 5-Fluorouracil

S. Chatterjee, P. Naeli, N. Simms, A. Garzia, A. Hackett, K. Coyle, P. Harris Snell, T. McGirr, T. N. Sawant, K. Dang, Z. V. Stoichkova, T. Alain, T. Tuschl, S. S. McDade, D. Longley, , S. M. Jafarnejad

This study shows that 5-Fluorouracil induces ribosome collisions, which are mitigated by the RQC mechanism through mTOR-dependent regulation of RQC factors.

bioRxiv · Dec 26, 2023Cell Biology

Repression of mRNA translation initiation by GIGYF1 via blocking the eIF3-eIF4G1 interaction

J.-H. Choi, J. Luo, G. G. Hesketh, S. Guo, A. Pistofidis, R. J. Ladak, Y. An, T. Alain, M. Schmeing, A.-C. Gingras, T. Duchaine, X. Zhang, N. Sonenberg, S. M. Jafarnejad

This study identifies GIGYF1 as a repressor of mRNA translation by disrupting the eIF3-eIF4G1 interaction, enhancing host immune response by derepressing Ifnb1 mRNA.

bioRxiv · Oct 14, 2023Cell Biology

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

J.-H. Choi, X. Zhang, C. Zhang, D. L. Dai, J. Luo, R. Ladak, Q. Li, S. Wiebe, A. C. H. Liu, X. Ran, J. Yang, P. Naeli, A. Garzia, L. Zhou, N. Mahmood, , N. Sonenberg

This study identifies NSP2-induced repression of Ifnb1 mRNA translation as a mechanism by which SARS-CoV-2 suppresses IFN-β production.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

Identification of SARS-CoV2-mediated suppression of NRF2 signaling reveals a potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

D. Olagnier, E. Farahani, J. Thyrsted, J. B. Cadanet, A. Herengt, M. Idorn, A. Hait, B. Hernaez, A. Knudsen, M. B. Iversen, M. Schilling, S. E. Jorgensen, M. Thomsen, L. Reinert, M. Lappe, , C. K. Holm

The paper identifies NRF2 agonists 4-OI and DMF as inhibitors of SARS-CoV2 replication and inflammatory responses, effective against multiple viruses.

bioRxiv · Jul 16, 2020Microbiology

Translational profiling of macrophages infected with Leishmania donovani identifies mTOR- and eIF4A-sensitive immune-related transcripts

V. Chaparro, L.-P. Leroux, L. Masvidal, J. Lorent, T. E. Graber, A. Zimmermann, G. Arango Duque, A. Descoteaux, T. Alain, O. Larsson, M. Jaramillo

This study identifies mTOR- and eIF4A-sensitive immune-related transcripts in Leishmania donovani-infected macrophages, showing their role in modulating mRNA metabolism and immune responses.

bioRxiv · Dec 20, 2019Immunology

LARP1 is a major phosphorylation substrate of mTORC1

B. D. Fonseca, J.-J. Jia, A. K. Hollensen, R. Pointet, H.-D. Hoang, M. R. Niklaus, I. A. Pena, R. M. Lahr, E. M. Smith, J. Hearnden, X.-D. Wang, A.-D. Yang, G. Celucci, T. E. Graber, C. Dajadian, , T. Alain

This study identifies LARP1 as a major phosphorylation substrate of mTORC1 and elucidates its role in regulating TOP mRNA translation.

bioRxiv · Dec 8, 2018 · PreprintBiochemistry