METTL3 inhibitors for epitranscriptomic modulation of cellular processes
E. V. Moroz-Omori, D. Huang, R. K. Bedi, S. J. Cheriyamkunnel, E. Bochenkova, A. Dolbois, M. D. Rzeczkowski, L. Wiedmer, A. Caflisch
This study identifies a METTL3 inhibitor, UZH1a, which reduces m6A methylation and inhibits leukemia cell growth, while its enantiomer UZH1b is inactive.
bioRxiv · Sep 25, 2020Biochemistry