Author

L. Wiedmer

Boston Foundation

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Approach:statistical model· 3 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Caflisch· 3 shared Amine SadokiD· 2 shared Bernhard FaschingiD· 2 shared Bradley DeMarco· 2 shared Camille Staehly· 2 shared Chao QuaniD· 2 shared D. Huang· 2 shared Débora BonenfantiD· 2 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMicrobiology

A. Caflisch

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Mining the CRBN Target Space Redefines Rules for Molecular Glue-induced Neosubstrate Recognition

Georg Petzold, Pablo Gaínza, Stefano Annunziato, Ilaria Lamberto, Peter Trenh, Laura A. McAllister, Bradley DeMarco, Laura Schwander, R.D. Bunker, Mary Zlotosch, Rohitha Sriramaratnam, Samuel Gilberto, Gerasimos Langousis, Etienne J. Donckèle, Chao Quan, , Sharon A. Townson

The paper predicts over 1,400 CRBN-compatible β-hairpin G-loop proteins and validates 22 neosubstrates, redefining rules for molecular glue-induced degradation.

Science · Jul 3, 2025Peer-reviewedBiochemistry

Molecular surface mimicry enables CRBN to target G3BP2 for degradation

Stefano Annunziato, Chao Quan, Etienne J. Donckèle, Ilaria Lamberto, R.D. Bunker, Mary Zlotosch, Laura Schwander, A. Murthy, L. Wiedmer, Camille Staehly, Michelle Matysik, Samuel Gilberto, Despina Kapsitidou, Daric Wible, Gian Marco De Donatis, , Georg Petzold

This study identifies a novel binding mechanism of G3BP2 to CRBN through an unconventional site, expanding the understanding of CRBN's neosubstrate recognition.

bioRxiv · Apr 30, 2025 · PreprintMolecular Biology

Combined computational and cellular screening identifies synergistic inhibition of SARS-CoV-2 by lenvatinib and remdesivir

M. O. Pohl, I. Busnadiego, F. Marrafino, L. Wiedmer, A. Hunziker, S. Fernbach, I. Glas, E. V. Moroz-Omori, B. G. Hale, A. Caflisch, S. Stertz

This study combines computational screening and cellular assays to identify lenvatinib and remdesivir as synergistic inhibitors of SARS-CoV-2 replication in Vero-CCL81 cells.

bioRxiv · Mar 19, 2021Microbiology

METTL3 inhibitors for epitranscriptomic modulation of cellular processes

E. V. Moroz-Omori, D. Huang, R. K. Bedi, S. J. Cheriyamkunnel, E. Bochenkova, A. Dolbois, M. D. Rzeczkowski, L. Wiedmer, A. Caflisch

This study identifies a METTL3 inhibitor, UZH1a, which reduces m6A methylation and inhibits leukemia cell growth, while its enantiomer UZH1b is inactive.

bioRxiv · Sep 25, 2020Biochemistry

Flexible binding of m6A reader protein YTHDC1 to its preferred RNA motif

Y. Li, R. K. Bedi, L. Wiedmer, D. Huang, P. Sledz, A. Caflisch

This study investigates how YTHDC1 binds to m6A-containing RNA motifs using simulations and experiments, revealing flexible 5 terminus interactions and conformational shifts.

bioRxiv · Sep 30, 2019Biophysics