Author

R. K. Bedi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Assay:structural biology· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

A. Caflisch· 3 shared D. Huang· 3 shared L. Wiedmer· 2 shared Y. Li· 2 shared A. Dolbois· 1 shared D. Coelho· 1 shared E. Bochenkova· 1 shared E. Braud· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

A. Caflisch

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Author profile →

3 papers

Recent·Most cited

The catalytic mechanism of the RNA methyltransferase METTL3

I. Corbeski, P. A. Vargas-Rosales, R. K. Bedi, J. Deng, D. Coelho, E. Braud, L. Iannazzo, Y. Li, D. Huang, M. Etheve-Quelquejeu, Q. Cui, A. Caflisch

This study reveals the catalytic mechanism of METTL3-14 by identifying two adenosine binding conformations, the methyl transfer transition state, and the roles of key residues in catalysis.

bioRxiv · Sep 6, 2023 · PreprintBiochemistry

METTL3 inhibitors for epitranscriptomic modulation of cellular processes

E. V. Moroz-Omori, D. Huang, R. K. Bedi, S. J. Cheriyamkunnel, E. Bochenkova, A. Dolbois, M. D. Rzeczkowski, L. Wiedmer, A. Caflisch

This study identifies a METTL3 inhibitor, UZH1a, which reduces m6A methylation and inhibits leukemia cell growth, while its enantiomer UZH1b is inactive.

bioRxiv · Sep 25, 2020Biochemistry

Flexible binding of m6A reader protein YTHDC1 to its preferred RNA motif

Y. Li, R. K. Bedi, L. Wiedmer, D. Huang, P. Sledz, A. Caflisch

This study investigates how YTHDC1 binds to m6A-containing RNA motifs using simulations and experiments, revealing flexible 5 terminus interactions and conformational shifts.

bioRxiv · Sep 30, 2019Biophysics