Centriolar subdistal appendages promote double strand break repair through homologous recombination
G. Rodriguez-Real, A. Dominguez-Calvo, R. Prados-Carvajal, A. Bayona-Feliu, S. Gomes-Pereira, F. R. Balestra, P. Huertas
This study shows centriolar subdistal appendages and CEP170 promote homologous recombination by enabling DNA end resection, and their loss increases DNA damage sensitivity and correlates with cancer prognosis.
bioRxiv · Oct 19, 2022Cell Biology