Simulating the human tumor microenvironment in colorectal cancer organoids in vitro and in vivo
M. Devarasetty, A. Dominijanni, S. Herberg, E. Shelkey, A. Skardal, S. Soker
This study creates human colorectal cancer organoids with stromal ECM layers, showing they maintain ECM architecture in vivo and induce epithelial or mesenchymal phenotypes based on TME order.
bioRxiv · Nov 1, 2019Cancer Biology