Author

A. Skardal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:organoid / primary culture· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

H. Sivakumar· 2 shared S. Herberg· 2 shared S. Soker· 2 shared A. Dominijanni· 1 shared A. Maycock· 1 shared A. Mazzocchi· 1 shared C. Clark· 1 shared E. Opara· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

H. Sivakumar

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Author profile →

3 papers

Recent·Most cited

A 3D adrenocortical carcinoma tumor platform for preclinical modeling of drug response and matrix metalloproteinase activity

P. Dedhia, H. Sivakumar, M. A. Rodriguez, K. G. Nairon, J. M. Zent, X. Zheng, K. Jones, L. Popova, J. L. Leight, A. Skardal

This paper develops a 3D adrenocortical carcinoma tumor platform to study drug response and MMP activity, showing decreased drug sensitivity and active MMP-mediated invasion in 3D.

bioRxiv · Jan 24, 2023Cancer Biology

Engineering a thixotropic and biochemically tunable hyaluronan and collagen bioink for biofabrication of multiple tissue construct types

J. Aleman, H. Sivakumar, T. DePalma, Y. Zhou, A. Mazzocchi, R. C. Huntwork, K. M. Yoo, S. Banks, C. Clark, A. Maycock, K. Leaks, K. Enck, E. Opara, P. Gatenholm, M. Welker, , A. Skardal

This paper develops a tunable bioink using collagen and hyaluronan with thixotropic properties and modular ECM components to support multiple tissue types in 3D bioprinting.

bioRxiv · Sep 1, 2021 · PreprintBioengineering

Simulating the human tumor microenvironment in colorectal cancer organoids in vitro and in vivo

M. Devarasetty, A. Dominijanni, S. Herberg, E. Shelkey, A. Skardal, S. Soker

This study creates human colorectal cancer organoids with stromal ECM layers, showing they maintain ECM architecture in vivo and induce epithelial or mesenchymal phenotypes based on TME order.

bioRxiv · Nov 1, 2019Cancer Biology