MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes
V. S. Chelakkot, K. Liu, E. Yoshioka, S. Saha, D. Xu, M. Licursi, A. Dorward, K. Hirasawa
This study identifies RSK-ABCB1 and HIF-1-FECH pathways regulated by MEK that reduce PpIX accumulation in cancer cells.
bioRxiv · Apr 10, 2020Cancer Biology