Author

K. Hirasawa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cancer Biology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

D. Xu· 2 shared M. Licursi· 2 shared A. Dorward· 1 shared A. Sasaki· 1 shared A. Yamashita· 1 shared E. Yoshioka· 1 shared H. Ichiyanagi· 1 shared H. Iwanari· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

D. Xu

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Tackling Mitosis Domain Generalization in Histopathology Images with Color Normalization

S. Kondo, S. Kasai, K. Hirasawa

The paper proposes a method for mitosis detection in histopathology images using color normalization and object detection, achieving an F1 score of 0.716 on a test set.

bioRxiv · Aug 23, 2022 · PreprintBioengineering

Antiviral roles of interferon regulatory factor (IRF)-1, 3 and 7 against human coronavirus infection

D. Xu, J. K. S. Duncan, M. Licursi, J. Gohda, Y. Kawaguchi, K. Hirasawa

This study investigates the antiviral roles of IRF1, IRF3, and IRF7 against human coronavirus infection, finding that IRF3 is critical for restricting 229E and OC43 infections.

bioRxiv · Mar 24, 2022 · PreprintMicrobiology

Structure and mechanism of oxalate transporter OxlT in an oxalate-degrading bacterium in the gut microbiota

T. Jaunet-Lahary, T. Shimamura, M. Hayashi, N. Nomura, K. Hirasawa, T. Shimizu, M. Yamashita, K. Kojima, Y. Sudo, T. Tamura, H. Iwanari, T. Hamakubo, S. Iwata, K.-i. Okazaki, T. Hirai, A. Yamashita

This study determines the crystal structures of OxlT, an oxalate transporter, and reveals its mechanism for selective oxalate uptake and exclusion of other carboxylates.

bioRxiv · Nov 15, 2021Biochemistry

Development of Microsatellite Markers for a Soricid Water Shrew Chimarrogale platycephalus, and the Success of Individual Identification Using It.

H. Yamazaki, T. Sekiya, S. Nagayama, K. Hirasawa, K. Tokura, A. Sasaki, H. Ichiyanagi, K. Tojo

This study develops microsatellite markers for the endangered water shrew Chimarrogale platycephalus and validates their ability to uniquely identify individuals.

bioRxiv · May 21, 2020Evolutionary Biology

MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes

V. S. Chelakkot, K. Liu, E. Yoshioka, S. Saha, D. Xu, M. Licursi, A. Dorward, K. Hirasawa

This study identifies RSK-ABCB1 and HIF-1-FECH pathways regulated by MEK that reduce PpIX accumulation in cancer cells.

bioRxiv · Apr 10, 2020Cancer Biology