Author

A. E. Atang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. W. Avery· 3 shared A. R. Keller· 2 shared D. D. Thomas· 2 shared R. T. Rebbeck· 2 shared S. A. Denha· 2 shared A. L. Carter· 1 shared B. Svensson· 1 shared P. Guhathakurta· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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3 shared papersBiochemistry

A. W. Avery

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cardiomyopathy-Associated Variants Alter the Structure and Function of the α-Actinin-2 Actin-Binding Domain

A. E. Atang, R. T. Rebbeck, D. D. Thomas, A. W. Avery

This study investigates how cardiomyopathy-associated variants in the α-actinin-2 actin-binding domain affect its structure and function, finding that some variants disrupt actin binding and may contribute to disease.

bioRxiv · May 9, 2023Biochemistry

Increased actin binding is a shared molecular consequence of numerous spinocerebellar ataxia mutations in β-III-spectrin

A. E. Atang, A. R. Keller, S. A. Denha, A. W. Avery

This study shows that multiple SCA5 mutations increase actin-binding affinity, with some mutations causing earlier symptom onset.

bioRxiv · Feb 20, 2023 · PreprintBiochemistry

Identification of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia

P. Guhathakurta, R. T. Rebbeck, S. A. Denha, A. R. Keller, A. L. Carter, A. E. Atang, B. Svensson, D. D. Thomas, T. S. Hays, A. W. Avery

The paper develops an in vitro FRET assay to identify small molecule modulators of the L253P mutant β-III-spectrin actin-binding domain, identifying potential drug candidates for SCA5 treatment.

bioRxiv · Nov 8, 2022 · PreprintBiophysics