R. T. Rebbeck

Kinetics and Mapping of Ca-driven Calmodulin conformations on Skeletal and Cardiac Muscle Ryanodine Receptors

The paper uses FRET to study CaM conformational changes on RyR in skeletal and cardiac muscle, finding CaM becomes more compact at high Ca2+ and showing isoform-specific differences.

Molecular Mechanism of a FRET Biosensor for the Cardiac Ryanodine Receptor Pathologically Leaky State

This paper uses FRET to study how DPc10 and CaM interact with RyR2, revealing their distinct effects on channel function and structural changes.

RyR2 Binding of an Antiarrhythmic Cyclic Depsipeptide Mapped Using Confocal Fluorescence Lifetime Detection of FRET

The paper maps the binding site of ent-verticilide on RyR2 using FRET and computational methods, identifying two potential loci within the RyR2 structure.

Cardiomyopathy-Associated Variants Alter the Structure and Function of the α-Actinin-2 Actin-Binding Domain

This study investigates how cardiomyopathy-associated variants in the α-actinin-2 actin-binding domain affect its structure and function, finding that some variants disrupt actin binding and may contribute to disease.

FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators

The paper uses a FRET assay to screen compounds affecting the cardiac SERCA pump, identifying activators and inhibitors with potential therapeutic applications for heart failure.

Identification of β-III-spectrin actin-binding modulators for treatment of spinocerebellar ataxia

The paper develops an in vitro FRET assay to identify small molecule modulators of the L253P mutant β-III-spectrin actin-binding domain, identifying potential drug candidates for SCA5 treatment.

Cardiac RyR N-terminal region biosensors for FRET-based high-throughput screening

This study develops FRET-based biosensors to screen for RyR modulators, identifying novel inhibitors and activators with therapeutic potential.