Endomembrane targeting of human OAS1 p46 augments antiviral activity
F. W. Soveg, J. Schwerk, N. S. Gokhale, K. Cerosaletti, J. R. Smith, E. Pairo-Castineira, A. M. Kell, A. Forero, S. A. Zaver, K. Esser-Nobis, J. Roby, T.-Y. Hsiang, S. Ozarkar, J. M. Clingan, E. T. McAnarney, , R. Savan
This study shows that the OAS1 p46 isoform, targeted to the endomembrane system, enhances antiviral activity against RNA viruses and is associated with COVID-19 severity.
bioRxiv · Apr 21, 2021Immunology