PTPN22 R620W gene editing in T cells enhances low avidity TCR responses
W. Anderson, F. Barahmand-pour-Whitman, P. S. Linsley, K. Cerosaletti, J. H. Buckner, D. J. Rawlings
This study edits the PTPN22 R620W variant in T cells to show it enhances low avidity TCR responses, contributing to autoimmunity risk.
bioRxiv · Jul 21, 2022Immunology