Author

D. B. Stetson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 6

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

J. M. Snyder· 2 shared M. Gale· 2 shared S. Cambier· 2 shared A. E. L. Stone· 1 shared A. Forero· 1 shared A. M. Kell· 1 shared A. Moon· 1 shared B. D. Bryson· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersImmunology

J. M. Snyder

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Early cellular mechanism of type I interferon-driven susceptibility to tuberculosis

D. I. Kotov, O. V. Lee, S. A. Fattinger, C. Langner, J. V. Guillen, J. M. Peters, A. Moon, E. M. Burd, K. C. Witt, D. B. Stetson, D. L. Jaye, B. D. Bryson, R. E. Vance

This study identifies interstitial macrophages and plasmacytoid dendritic cells as key producers of type I IFN during Mtb infection, showing their role in driving tuberculosis pathogenesis through IFN-driven mechanisms.

bioRxiv · Oct 6, 2022Immunology

ABCC1/MRP1 exports cGAMP and modulates cGAS-dependent immunity

J. H. Maltbaek, J. M. Snyder, D. B. Stetson

This study identifies ABCC1/MRP1 as an ATP-dependent cGAMP exporter that modulates cGAS-STING signaling and type I interferon production.

bioRxiv · Dec 3, 2021 · PreprintImmunology

Endomembrane targeting of human OAS1 p46 augments antiviral activity

F. W. Soveg, J. Schwerk, N. S. Gokhale, K. Cerosaletti, J. R. Smith, E. Pairo-Castineira, A. M. Kell, A. Forero, S. A. Zaver, K. Esser-Nobis, J. Roby, T.-Y. Hsiang, S. Ozarkar, J. M. Clingan, E. T. McAnarney, , R. Savan

This study shows that the OAS1 p46 isoform, targeted to the endomembrane system, enhances antiviral activity against RNA viruses and is associated with COVID-19 severity.

bioRxiv · Apr 21, 2021Immunology

PKR and the Integrated Stress Response drive immunopathology caused by ADAR1 mutation

M. Maurano, J. M. Snyder, C. Connelly, J. Henao-Mejia, C. Sidrauski, D. B. Stetson

This study shows that PKR and the integrated stress response drive immunopathology in ADAR1 mutation models, and an ISR inhibitor prevents disease.

bioRxiv · Nov 30, 2020 · PreprintImmunology

Human DNA-PK activates a STING-independent DNA sensing pathway

K. Burleigh, J. Maltbaek, S. Cambier, R. Green, M. Gale, R. C. James, D. B. Stetson

The paper identifies a STING-independent DNA sensing pathway in human cells, mediated by DNA-PK, and shows its role in antiviral responses and distinct activation from DNA damage.

bioRxiv · Mar 23, 2019Immunology

cGAS is predominantly a nuclear protein

H. E. Volkman, S. Cambier, E. E. Gray, D. B. Stetson

This study shows that cGAS is mainly a nuclear protein, not cytosolic, and is tightly tethered to chromatin to prevent constitutive activation by self DNA.

bioRxiv · Dec 4, 2018 · PreprintImmunology