Author

A. E. Lukacher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

K. N. Ayers· 2 shared M. D. Lauver· 2 shared A. M. Pham· 1 shared C. M. Bator· 1 shared C. S. Abendroth· 1 shared C. S. Netherby-Winslow· 1 shared C. S. Specht· 1 shared D. G. Haas· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersImmunology

K. N. Ayers

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cellular senescence preserves viral genome maintenance

A. M. Pham, L. E. Ortiz, A. E. Lukacher, H. J. Kwun

This study shows that MCPyV genome maintenance depends on senescence induced by the virus's large T antigen in human fibroblasts, suggesting senolytic drugs could prevent Merkel cell carcinoma.

bioRxiv · Jul 12, 2022Microbiology

T Cell Deficiency Precipitates Antibody Evasion and Emergence of Neurovirulent Polyomavirus

M. D. Lauver, K. N. Ayers, S. N. Carey, C. S. Specht, C. S. Abendroth, A. E. Lukacher

The paper shows that T cell deficiency allows JCPyV to develop antibody-escape mutations, leading to neurovirulent variants.

bioRxiv · Feb 25, 2022Immunology

Antibody Escape by Polyomavirus Capsid Mutation Facilitates Neurovirulence

M. D. Lauver, D. J. Goetschius, C. S. Netherby-Winslow, K. N. Ayers, G. Jin, D. G. Haas, E. L. Frost, S. H. Cho, C. M. Bator, S. M. Bywaters, N. D. Christensen, S. L. Hafenstein, A. E. Lukacher

The paper shows a JCPyV-PML VP1 mutation enables antibody escape and neurovirulence in mice.

bioRxiv · Jul 14, 2020Immunology