Author

H. J. Kwun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:proteomics· 1

Frequent Co-Authors

L. E. Ortiz· 2 shared A. E. Lukacher· 1 shared A. M. Pham· 1 shared A. Whitehouse· 1 shared N. Nwogu· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 6 mutual co-author links

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2 shared papersMicrobiology

L. E. Ortiz

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2 papers

Recent·Most cited

Cellular senescence preserves viral genome maintenance

A. M. Pham, L. E. Ortiz, A. E. Lukacher, H. J. Kwun

This study shows that MCPyV genome maintenance depends on senescence induced by the virus's large T antigen in human fibroblasts, suggesting senolytic drugs could prevent Merkel cell carcinoma.

bioRxiv · Jul 12, 2022Microbiology

Merkel Cell Polyomavirus Small Tumor Antigen Activates Matrix Metallopeptidase-9 Gene Expression for Cell Migration and Invasion

N. Nwogu, L. E. Ortiz, A. Whitehouse, H. J. Kwun

This study shows MCV sT activates MMP-9 expression via the LSD domain, promoting cell migration and invasion in MCC, suggesting MMP-9 as a therapeutic target.

bioRxiv · Mar 2, 2020Microbiology