Oxidized thioredoxin-1 restrains the NLRP1 inflammasome
D. P. Ball, A. E. Wang, C. D. Warren, Q. Wang, A. R. Griswold, S. D. Rao, D. A. Bachovchin
This study identifies oxidized thioredoxin-1 as a repressor of NLRP1 inflammasome activation, showing that mutations impair this interaction and cause autoinflammatory disease.
bioRxiv · Sep 20, 2021Immunology