Author

S. D. Rao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

A. R. Griswold· 3 shared D. A. Bachovchin· 3 shared D. P. Ball· 3 shared Q. Wang· 2 shared A. Bhattacharjee· 1 shared A. E. Wang· 1 shared A. J. Chui· 1 shared C. D. Warren· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersImmunology

A. R. Griswold

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3 papers

Recent·Most cited

Cytosolic peptide accumulation activates the NLRP1 and CARD8 inflammasomes

E. L. Orth-He, H.-C. Huang, S. D. Rao, Q. Wang, Q. Chen, C. M. O'Mara, A. J. Chui, M. Saoi, A. R. Griswold, A. Bhattacharjee, D. P. Ball, J. R. Cross, D. A. Bachovchin

This study identifies cytosolic peptide accumulation as a danger signal that activates NLRP1 and CARD8 inflammasomes by promoting NT degradation and disrupting DPP9-mediated sequestration of CT fragments.

bioRxiv · Mar 22, 2022 · PreprintImmunology

Oxidized thioredoxin-1 restrains the NLRP1 inflammasome

D. P. Ball, A. E. Wang, C. D. Warren, Q. Wang, A. R. Griswold, S. D. Rao, D. A. Bachovchin

This study identifies oxidized thioredoxin-1 as a repressor of NLRP1 inflammasome activation, showing that mutations impair this interaction and cause autoinflammatory disease.

bioRxiv · Sep 20, 2021Immunology

Human caspase-1 autoproteolysis is required for ASC-dependent and -independent inflammasome activation

D. P. Ball, C. Y. Taabazuing, A. R. Griswold, E. L. Orth, S. D. Rao, I. B. Kotliar, D. C. Johnson, D. A. Bachovchin

This study shows that pro-caspase-1 autoproteolysis is required for both ASC-dependent and -independent inflammasome activation in human cells.

bioRxiv · Jun 24, 2019 · PreprintImmunology