L. Costa

The hypervirulent Group B Streptococcus HvgA adhesin promotes brain invasion through transcellular crossing of the choroid plexus

This study shows that the hypervirulent GBS CC17 strain uses the HvgA adhesin to invade the choroid plexus, crossing the blood-CSF barrier through transcellular transcytosis.

Stability of influenza A virus in droplets and aerosols is heightened by the presence of commensal respiratory bacteria.

This study shows that respiratory commensal bacteria enhance the stability of influenza A virus in droplets and aerosols, suggesting the microbiota may influence viral transmission risks.

Salt supersaturation as accelerator of influenza A virus inactivation in 1-μl droplets

This study quantifies how salt concentration affects influenza A virus inactivation in drying droplets and explains airborne virus transmission mechanisms.

Paridiprubart inhibits TLR4-dependant NF-κB activation by multiple pathogens

This study shows that paridiprubart, a TLR4 inhibitor, suppresses NF-κB activation by multiple pathogens including SARS-CoV-2 and bacterial agents.

Phase separation and molecular ordering of the prion-like domain of the thermosensory protein EARLY FLOWERING 3

The paper investigates the phase separation behavior of the prion-like domain of ELF3 in Arabidopsis, showing how polyQ length affects structural transitions and hydrogel formation.

The structure of pathogenic huntingtin exon-1 defines the bases of its aggregation propensity

This study investigates how the structure of pathogenic huntingtin exon-1 with expanded poly-Q tracts influences its aggregation propensity and fibril formation.

Structure and mechanics of the human Nuclear Pore Complex basket

The paper uses AFM and SMLM to show the human Nuclear Pore Complex basket is soft and conformationally flexible, enabling diverse cargo transport.

A tripartite complex HIV-1 Tat-cyclophilin A-capsid protein enables Tat encapsidation that is required for HIV-1 infectivity

This study identifies a Tat-CypA-CA tripartite complex that enables Tat encapsidation, which is essential for HIV-1 infectivity and viral production.

SARS-CoV-2 Infection Impacts Carbon Metabolism and Depends on Glutamine for Replication in Syrian Hamster Astrocytes

This study shows SARS-CoV-2 infection alters carbon metabolism in hamster astrocytes, with glutamine dependency for replication and links to neurological symptoms.

Genomic surveillance of SARS-CoV-2 reveals community transmission of a major lineage during the early pandemic phase in Brazil

This study analyzes SARS-CoV-2 genetic diversity in Brazil during the early pandemic phase, identifying community transmission of a major lineage and its spread to other countries.

MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis

The paper shows that MAGI1 loss in luminal breast cancer promotes tumorigenesis by activating the AMOTL2/p38 stress pathway, which is inhibited by MAGI1.

Quantitative Mapping of Free-Standing Lipid Membranes on Nano-Porous Mica Substrates

This study quantifies the mechanical properties of free-standing lipid membranes on nano-porous mica substrates, revealing differences in bending modulus and lipid ordering at pore edges.