J. Cortes

The structure of pathogenic huntingtin exon-1 defines the bases of its aggregation propensity

This study investigates how the structure of pathogenic huntingtin exon-1 with expanded poly-Q tracts influences its aggregation propensity and fibril formation.

In situ single-cell analysis of canonical breast cancer biomarkers: phenotypic heterogeneity and implications on response to HER2 targeting agents.

The paper analyzes HER2-positive breast cancer tumors at the single-cell level to identify phenotypic heterogeneity and its implications for response to HER2-targeted therapies.

Conformational buffering underlies functional selection in intrinsically disordered protein regions

The paper identifies conformational buffering as a mechanism that conserves spatial dimensions in disordered protein regions despite sequence variation, enabling functional selection.

Doxorubicin Induces Senescence in Intestinal Epithelial Cells

This study shows doxorubicin induces senescence in intestinal epithelial cells in vitro, characterized by increased cell size, senescence-associated β-galactosidase, and secretion of inflammatory factors.

A controlled thermoalgesic stimulation device to identify novel pain perception biomarkers

This paper introduces a device that measures brain and hemodynamic responses to thermal pain and identifies biomarkers using spectral entropy analysis.

Fungal communities in sediments along a depth gradient in the Eastern Tropical Pacific

The paper examines fungal diversity and community composition in marine sediments along a depth gradient in the Eastern Tropical Pacific, finding no strong effect of environmental factors on fungal community structure.

Clonal Evolution of Acute Myeloid Leukemia Revealed by High-Throughput Single-Cell Genomics

This study uses single-cell DNA sequencing to analyze clonal diversity in AML, revealing mutation co-occurrence, mutual exclusivity, and evolutionary patterns linked to treatment resistance and poor prognosis.

A new clinical tool to predict outcome in early-stage melanoma patients

The paper develops a prognostic tool using cytokine levels and Breslow thickness to predict metastasis risk in early-stage melanoma patients.

Hydrodynamic and electrophoretic properties of Trastuzumab/HER2 complexes. Experiments and modeling.

This study combines experiments and modeling to analyze the hydrodynamic and electrophoretic properties of Trastuzumab/HER2 complexes, identifying two distinct complexes and their biophysical characteristics.