Author

L. B. Chemes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

A. A. Malik· 1 shared A. Barozet· 1 shared A. Estana· 1 shared A. J. Auguste· 1 shared A. S. Holehouse· 1 shared A. Sagar· 1 shared A. Varese· 1 shared A.-C. Gingras· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

A. A. Malik

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

Y. Lu, T. Cho, S. Mukherjee, A. A. Malik, N. Gonzalez-Foutel, C. F. Suarez, D. Derovic, R. H. Oh, E. Langille, K. Al-Zahrani, Z. Lin, R. Tsai, V. Rotter, P. Ashton-Prolla, L. B. Chemes, , D. Schramek

This study uses CRISPR screens to identify factors regulating wild-type and mutant p53 stability, finding distinct regulators for different p53 mutants and their implications in cancer.

bioRxiv · Mar 13, 2022Cancer Biology

A novel bacterial protease inhibitor adjuvant in RBD-based COVID-19 vaccine formulations increases neutralizing antibodies, specific germinal center B cells and confers protection against SARS-CoV-2 infection.

L. M. Coria, L. M. Saposnik, C. Pueblas Castro, E. F. Castro, L. A. Bruno, W. B. Stone, P. S. Perez, M. L. Darriba, L. B. Chemes, J. Alcain, I. Mazzitelli, A. Varese, M. Salvatori, A. J. Auguste, D. E. Alvarez, , J. Cassataro

This paper evaluates RBD-based vaccine formulations with different adjuvants, finding that U-Omp19+Alum significantly increases neutralizing antibodies, B cells, and provides protection against SARS-CoV-2.

bioRxiv · Dec 7, 2021 · PreprintImmunology

Conformational buffering underlies functional selection in intrinsically disordered protein regions

N. S. Gonzalez-Foutel, W. M. Borcherds, J. Glavina, S. Barrera-Vilarmau, A. Sagar, A. Estana, A. Barozet, G. Fernandez-Ballester, C. Blanes-Mira, I. E. Sanchez, G. de Prat Gay, J. Cortes, P. Bernado, R. V. Pappu, A. S. Holehouse, , L. B. Chemes

The paper identifies conformational buffering as a mechanism that conserves spatial dimensions in disordered protein regions despite sequence variation, enabling functional selection.

bioRxiv · May 14, 2021Biophysics