Author

H. Begthel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:organoid / primary culture· 3 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

H. Clevers· 3 shared J. Korving· 2 shared P. J. Peters· 2 shared A. F. M. Dost· 1 shared A. Giladi· 1 shared A. Lyubimova· 1 shared A. Papaspyropoulos· 1 shared A. Sexton-Oates· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersCell Biology

H. Clevers

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Tuft cells act as regenerative stem cells in the human intestine

L. Huang, J. H. Bernink, A. Giladi, D. Krueger, G. J. F. van Son, M. H. Geurts, G. Busslinger, L. Lin, M. Zandvliet, P. J. Peters, C. Lopez-Iglesias, C. J. Buskens, W. A. Bemelman, H. Begthel, H. Clevers

The paper identifies four human tuft cell states, showing they function as radiation-resistant stem cells capable of regenerating the intestinal epithelium.

bioRxiv · Mar 17, 2024Cell Biology

Druggable Growth Dependencies and Tumor Evolution Analysis in Patient-Derived Organoids of Neuroendocrine Cancer

T. L. Dayton, N. Alcala, L. Moonen, L. den Hartigh, L. Mangiante, L. Lap, A. F. M. Dost, J. Beumer, S. Levy, R. S. van Leeuwaarde, W. M. Hackeng, K. Samsom, C. Voegele, A. Sexton-Oates, H. Begthel, , H. Clevers

This study establishes patient-derived tumor organoids (PDTOs) for neuroendocrine cancers, identifies therapeutic vulnerabilities, and highlights EGF dependency in pulmonary neuroendocrine tumors.

bioRxiv · Oct 31, 2022Cancer Biology

Long-term expanding human airway organoids for disease modelling.

N. Sachs, D. D. Zomer-van Ommen, A. Papaspyropoulos, I. Heo, L. Bottinger, D. Klay, F. Weeber, G. Huelsz-Prince, N. Iakobachvili, M. C. Viveen, A. Lyubimova, L. Teeven, S. Derakhshan, J. Korving, H. Begthel, , H. Clevers

This study establishes long-term-expanding human airway organoids from broncho-alveolar biopsies or lavage material, enabling disease modeling of cystic fibrosis, lung cancer, and RSV infection.

bioRxiv · May 9, 2018Cell Biology