Neutralizing monoclonal antibodies elicited by mosaic RBD nanoparticles bind conserved sarbecovirus epitopes
C. Fan, A. A. Cohen, M. Park, A. F.-H. Hung, J. R. Keeffe, P. N. Gnanapragasam, Y. E. Lee, L. M. Kakutani, Z. Wu, K. E. Malecek, J. C. Williams, P. J. Bjorkman
This study identifies cross-reactive monoclonal antibodies against conserved sarbecovirus epitopes using mosaic RBD nanoparticles and shows their neutralization potential against SARS-CoV-2 variants and animal sarbecoviruses.
bioRxiv · Jun 28, 2022Immunology