Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
12 papers
Recent·Most cited
E. Wang, A. A. Cohen, L. F. Caldera, J. R. Keeffe, A. V. Rorick, Y. M. Aida, P. N. P. Gnanapragasam, P. J. Bjorkman, A. K. Chakraborty
The paper designs mosaic nanoparticles with SARS-like betacoronavirus RBDs to enhance cross-reactive immune responses in mice, finding that mosaic-7COM elicits stronger responses against zoonotic sarbecoviruses and Omicrons.
bioRxiv · Feb 28, 2024Immunology
A. A. Cohen, J. R. Keeffe, A. Schiepers, S. E. Dross, A. J. Greaney, A. V. Rorick, H. Gao, P. N. P. Gnanapragasam, C. Fan, A. P. West, A. I. Ramsingh, J. H. Erasmus, J. D. Pata, H. Muramatsu, N. Pardi, , P. J. Bjorkman
The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.
bioRxiv · Feb 8, 2024Immunology
N. Youssef, S. Gurev, F. Ghantous, K. P. Brock, J. A. Jaimes, N. N. Thadani, A. Dauphin, A. C. Sherman, L. Yurkovetskiy, D. Soto, R. Estanboulieh, B. Kotzen, P. Notin, A. W. Kollasch, A. A. Cohen, , D. Marks
The paper designs SARS-CoV-2 Spike proteins with novel mutations to evaluate vaccine effectiveness against future viral variants using a deep learning model.
bioRxiv · Oct 8, 2023Immunology
R. A. Hills, T. K. Tan, A. A. Cohen, J. R. Keefe, A. H. Keeble, P. N. Gnanapragasam, K. N. Storm, M. L. Hill, S. Liu, J. Gilbert-Jaramillo, M. Afzal, A. Napier, W. S. James, P. J. Bjorkman, A. R. Townsend, M. Howarth
A vaccine candidate with polyprotein antigens displayed on nanocages induces neutralizing antibodies to multiple SARS-like coronaviruses.
bioRxiv · Feb 24, 2023 · PreprintImmunology
M. A. Hoffmann, Z. Yang, K. E. Huey-Tubman, A. A. Cohen, P. N. Gnanapragasam, L. M. Nakatomi, K. N. Storm, W. J. Moon, P. J. Lin, P. J. Bjorkman
This study develops a vaccine technology using mRNA encoding spike-EABR to generate eVLPs, enhancing antibody and T-cell responses against SARS-CoV-2 variants.
bioRxiv · Dec 26, 2022 · PreprintImmunology
C. Fan, A. A. Cohen, M. Park, A. F.-H. Hung, J. R. Keeffe, P. N. Gnanapragasam, Y. E. Lee, L. M. Kakutani, Z. Wu, K. E. Malecek, J. C. Williams, P. J. Bjorkman
This study identifies cross-reactive monoclonal antibodies against conserved sarbecovirus epitopes using mosaic RBD nanoparticles and shows their neutralization potential against SARS-CoV-2 variants and animal sarbecoviruses.
bioRxiv · Jun 28, 2022Immunology
A. A. Cohen, N. A. van Doremalen, A. J. Greaney, H. Andersen, A. Sharma, T. N. Starr, J. R. Keeffe, C. Fan, J. E. Schulz, P. N. P. Gnanapragasam, L. M. Kakutani, A. P. West, G. Saturday, Y. E. Lee, H. Gao, , P. J. Bjorkman
This study designs mosaic RBD nanoparticles to elicit antibodies against conserved sarbecovirus epitopes, showing broader protection against SARS-CoV-2 variants and animal sarbecoviruses in animal models.
bioRxiv · Mar 25, 2022 · PreprintMicrobiology
C. A. Jette, A. A. Cohen, P. N. P. Gnanapragasam, F. Muecksch, Y. E. Lee, K. E. Huey-Tubman, F. Schmidt, T. Hatziioannou, P. D. Bieniasz, M. C. Nussenzweig, A. P. West, J. R. Keeffe, P. Bjorkman, C. O. Barnes
The paper identifies two class 4 anti-RBD antibodies from COVID-19 donors that broadly neutralize zoonotic sarbecoviruses and SARS-CoV-2 variants with high potency.
bioRxiv · Apr 23, 2021Immunology
A. A. Cohen, P. N. P. Gnanapragasam, Y. E. Lee, S. Ou, L. M. Kakutani, J. R. Keeffe, C. O. Barnes, H.-J. Wu, M. Howarth, A. P. West, M. C. Nussenzweig, P. J. Bjorkman
The paper demonstrates that mosaic nanoparticles displaying multiple coronavirus RBDs induce cross-reactive and neutralizing antibodies against SARS-CoV-2 and zoonotic coronaviruses in mice.
bioRxiv · Nov 17, 2020Immunology
F. Dufour, P.-E. Jacques, A. A. Cohen
The paper identifies 230 gene ontology systems with negative DM-age correlations in human peripheral blood, suggesting loss of responsiveness during aging.
bioRxiv · Sep 9, 2020 · PreprintCell Biology
A. A. Cohen, Z. Yang, P. Gnanapragasam, S. Ou, K.-M. Dam, H. Wang, P. J. Bjorkman
This study constructs and characterizes influenza HA trimer-displaying nanoparticles and evaluates their immunogenicity, finding that mosaic particles do not consistently elicit broader immune responses than homotypic ones.
bioRxiv · Jan 18, 2020Immunology
S. Samandi, A. V. Roy, V. Delcourt, J.-F. Lucier, J. Gagnon, M. C. Beaudoin, B. Vanderperre, M.-A. Breton, J.-F. Jacques, M. Brunelle, J. Motard, I. Gagnon-Arsenault, I. Fournier, A. Ouangraoua, D. J. Hunting, , X. Roucou
The paper identifies alternative open reading frames (altORFs) that encode small proteins, showing functional cooperation with larger proteins from the same gene.
bioRxiv · Sep 22, 2017Biochemistry