Author

A. Fountain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Assay:imaging· 3 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 1 Organism:mouse· 1

Frequent Co-Authors

R. J. Botelho· 2 shared S. Mamand· 2 shared A. Somerville· 1 shared C. Lancaster· 1 shared E. Somerville· 1 shared E. Tang· 1 shared G. T. Saffi· 1 shared J. Sheth· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

R. J. Botelho

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3 papers

Recent·Most cited

Arf1-PI4KIIIβ positive vesicles regulate phosphatidylinositol-3-phosphate signalling to facilitate the fission of lysosomal tubules.

M. Boutry, L. F. DiGiovanni, N. Demers, A. Fountain, S. Mamand, R. Botelho, P. K. Kim

This study identifies Arf1-PI4KIIIβ positive vesicles as regulators of PI(3)P signaling essential for lysosomal tubule fission across different lysosomal organelles.

bioRxiv · Mar 24, 2023Cell Biology

Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition

G. T. Saffi, E. Tang, S. Inpanathan, S. Mamand, A. Fountain, L. Salmena, R. J. Botelho

This study shows that reactive oxygen species (ROS) prevent lysosome coalescence during PIKfyve inhibition through distinct mechanisms depending on the ROS type.

bioRxiv · Jun 17, 2021Cell Biology

Phagosome resolution regenerates lysosomes and maintains the degradative capacity in phagocytes

C. Lancaster, A. Fountain, R. Dayam, E. Somerville, J. Sheth, V. Jacobelli, A. Somerville, M. Terebiznik, R. J. Botelho

This study shows that phagosome resolution through clathrin-dependent fragmentation regenerates lysosomes and maintains macrophage degradative capacity after multiple rounds of phagocytosis.

bioRxiv · May 14, 2020Cell Biology