P. K. Kim

Upregulated pexophagy limits the capacity of selective autophagy

The paper shows that increased pexophagy reduces the ability of selective autophagy to degrade mitochondria and protein aggregates, and this effect is observed in disease models.

Arf1-PI4KIIIβ positive vesicles regulate phosphatidylinositol-3-phosphate signalling to facilitate the fission of lysosomal tubules.

This study identifies Arf1-PI4KIIIβ positive vesicles as regulators of PI(3)P signaling essential for lysosomal tubule fission across different lysosomal organelles.

Hyaluronic Acid Fuels Pancreatic Cancer Growth

This study shows hyaluronic acid fuels pancreatic cancer metabolism by bypassing GFAT1 via the GlcNAc salvage pathway, enabling proliferation in nutrient-starved conditions.

Exploiting toxin internalization receptors to enhance delivery of proteins to lysosomes for enzyme replacement therapy

This study creates a chimera of diphtheria toxin and TPP1 to enhance lysosomal enzyme delivery, showing improved uptake and efficacy in a mouse model.

Hyperspectral super-resolution imaging with far-red emitting fluorophores using a thin-film tunable filter

The paper develops a method using a tunable thin-film filter to achieve hyperspectral super-resolution imaging with far-red fluorophores, demonstrating improved spectral resolution and two-color SMLM.

mTORC1 controls glycogen synthase kinase 3β nuclear localization and function

The paper shows mTORC1 inhibits GSK3β nuclear localization and function, linking metabolic signals to transcriptional control of biomass production.