Antibiotic heteroresistance generated by multi-copy plasmids
J. Hernandez-Beltran, J. Rodriguez-Beltran, B. Aguilar-Luviano, J. Velez-Santiago, O. Mondragon-Palomino, C. MacLean, A. Fuentes-Hernandez, A. San Millan, R. Pena-Miller
This study shows that multi-copy plasmids in E. coli generate antibiotic heteroresistance through copy number variability, enabling transient resistance and population regeneration.
bioRxiv · Aug 24, 2022 · PreprintMicrobiology