Author

R. Pena-Miller

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Approach:statistical model· 5 Organism:E. coli· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:bacteria (other)· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. San Millan· 4 shared J. Rodriguez-Beltran· 3 shared A. Alonso-del Valle· 2 shared J. DelaFuente· 2 shared R. Canton· 2 shared A. Fuentes-Hernandez· 1 shared A. Gonzalez-Casanova· 1 shared A. Quirant· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersMicrobiology

A. San Millan

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Antimicrobial resistance level and conjugation permissiveness shape plasmid distribution in clinical enterobacteria

A. Alonso-del Valle, L. Toribio-Celestino, A. Quirant, C. Tardio Pi, J. DelaFuente, R. Canton, E. Rocha, C. Ubeda, R. Pena-Miller, A. San Millan

The paper investigates how antimicrobial resistance levels and conjugation permissiveness influence plasmid distribution in clinical enterobacteria, showing that specific bacterial clones stabilize plasmid spread.

bioRxiv · Apr 3, 2023Microbiology

Antibiotic heteroresistance generated by multi-copy plasmids

J. Hernandez-Beltran, J. Rodriguez-Beltran, B. Aguilar-Luviano, J. Velez-Santiago, O. Mondragon-Palomino, C. MacLean, A. Fuentes-Hernandez, A. San Millan, R. Pena-Miller

This study shows that multi-copy plasmids in E. coli generate antibiotic heteroresistance through copy number variability, enabling transient resistance and population regeneration.

bioRxiv · Aug 24, 2022 · PreprintMicrobiology

Plasmid stability in fluctuating environments:population genetics of multi-copy plasmids

V. Miro Pina, J. C. R. Hernandez-Beltran, A. Siri-Jegousse, S. Palau, R. Pena-Miller, A. Gonzalez-Casanova

The paper models plasmid copy number optimization in bacteria under fluctuating selection, showing it depends on environmental change rates and balances stability with metabolic cost.

bioRxiv · Mar 15, 2022 · PreprintEvolutionary Biology

The distribution of plasmid fitness effects explains plasmid persistence in bacterial communities

A. Alonso-del Valle, R. Leon-Sampedro, J. Rodriguez-Beltran, J. DelaFuente, M. Hernandez-Garcia, P. Ruiz-Garbajosa, R. Canton, R. Pena-Miller, A. San Millan

The study determines the distribution of fitness effects for plasmid pOXA-48 in gut bacteria, showing quasi-neutral effects and beneficial effects in some isolates, and links plasmid persistence to bacterial diversity and phylogeny.

bioRxiv · Aug 1, 2020 · PreprintMicrobiology

Genetic dominance governs the evolution and spread of mobile genetic elements in bacteria

J. Rodriguez-Beltran, V. Sorum, M. Toll-Riera, C. de la Vega, R. Pena-Miller, A. San Millan

This study shows genetic dominance influences the evolution and spread of mobile genetic elements in bacteria by favoring dominant mutations and silencing recessive alleles in horizontally transferred genes.

bioRxiv · Dec 3, 2019Microbiology

Canonical host-pathogen tradeoffs subverted by mutations with dual benefits

R. E. Beardmore, I. Gudelj, J. R. Meyer, M. Hewlett, R. Pena-Miller

The paper shows that tradeoffs between host-parasite traits can become tradeups, supporting biodiversity through high-dimensional trait interactions.

bioRxiv · Oct 24, 2019Evolutionary Biology