J. Rodriguez-Beltran

This study shows that β-lactamase expression in E. coli induces collateral sensitivity to colistin and azithromycin, suggesting a therapeutic strategy to counter mobile AMR.

This study shows that multi-copy plasmids in E. coli generate antibiotic heteroresistance through copy number variability, enabling transient resistance and population regeneration.

This study tracks the evolution of plasmid-mediated antimicrobial resistance in hospitalized patients, revealing trade-offs between resistance levels and bacterial fitness.

The study determines the distribution of fitness effects for plasmid pOXA-48 in gut bacteria, showing quasi-neutral effects and beneficial effects in some isolates, and links plasmid persistence to bacterial diversity and phylogeny.

This study investigates collateral sensitivity associated with antibiotic resistance plasmids, showing its conservation in clinical isolates and potential for selective elimination of plasmid-carrying bacteria.

This study characterizes the dissemination routes of the carbapenem resistance plasmid pOXA-48 in a hospital setting using mechanistic models and genomic data.

This study shows genetic dominance influences the evolution and spread of mobile genetic elements in bacteria by favoring dominant mutations and silencing recessive alleles in horizontally transferred genes.

The paper investigates how clay and asbestos fibers induce DNA double-strand breaks in bacteria, potentially contributing to antibiotic resistance and genetic diversity.