Author

A. Garaizar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:deep learning· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:Hi-C· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

R. Collepardo-Guevara· 4 shared J. R. Espinosa· 3 shared A. R. Tejedor· 2 shared I. Sanchez-Burgos· 2 shared J. A. Joseph· 2 shared J. Ramirez· 2 shared A. Reinhardt· 1 shared D. Frenkel· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersBiophysics

R. Collepardo-Guevara

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5 papers

Recent·Most cited

Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it

A. R. Tejedor, I. Sanchez-Burgos, M. Estevez-Espinosa, A. Garaizar, R. Collepardo-Guevara, J. Ramirez, J. R. Espinosa

The paper shows that inter-protein β-sheets increase RNA-binding protein condensate viscosity and alter network connectivity, leading to gelation, but RNA can slow this process.

bioRxiv · Mar 30, 2022Biophysics

Dual RNA modulation of protein mobility and stability within phase-separated condensates

A. R. Tejedor, A. Garaizar, J. Ramirez, J. R. Espinosa

This study uses a coarse-grained model to show RNA modulates phase-separated condensate stability and transport properties through dual mechanisms depending on RNA concentration and length.

bioRxiv · Mar 5, 2021Biophysics

Nucleosome plasticity is a critical element of chromatin liquid-liquid phase separation and multivalent nucleosome interactions

S. E. Farr, E. J. Woods, J. A. Joseph, A. Garaizar, R. Collepardo-Guevara

This study develops a multiscale chromatin model to show that nucleosome plasticity drives chromatin LLPS and multivalent interactions.

bioRxiv · Nov 23, 2020Biophysics

Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence

S. M. Lichtinger, A. Garaizar, R. Collepardo-Guevara, A. Reinhardt

This paper evolves amino-acid sequences to modulate liquid-liquid phase separation in proteins, finding that sequence changes and environmental factors influence phase-separation behavior.

bioRxiv · Oct 20, 2020Biophysics

Oligonucleotides can act as superscaffolds that enhance liquid-liquid phase separation of intracellular mixtures

J. A. Joseph, J. R. Espinosa, I. Sanchez-Burgos, A. Garaizar, D. Frenkel, R. Collepardo-Guevara

This study shows oligonucleotides enhance liquid-liquid phase separation by acting as superscaffolds, increasing molecular connectivity and reducing barriers for phase separation in protein-oligonucleotide mixtures.

bioRxiv · Jan 24, 2020Biophysics