Author

A. R. Tejedor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:deep learning· 2 Approach:statistical model· 2 Approach:biophysical modeling· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

J. R. Espinosa· 4 shared J. Ramirez· 4 shared R. Collepardo-Guevara· 4 shared I. Sanchez-Burgos· 3 shared A. Garaizar· 2 shared B. P. O'Hara· 1 shared C. Chauvet· 1 shared C. Sbai· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersBiophysics

J. R. Espinosa

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Author profile →

5 papers

Recent·Most cited

Mechano-dependent sorbitol accumulation supports biomolecular condensate

S. Torrino, W. Oldham, A. R. Tejedor, I. Sanchez-Burgos, N. Rachedi, K. Fraissard, C. Chauvet, C. Sbai, B. P. O'Hara, S. Abelanet, F. Brau, S. Clavel, R. Collepardo-Guevara, J. Rene Espinosa, I. ben-sahra, T. BERTERO

The paper shows matrix stiffening promotes biomolecular condensation via sorbitol, a mechanosensitive metabolite, and demonstrates this in breast cancer.

bioRxiv · Jul 24, 2023Cell Biology

Location and concentration of aromatic-rich segments dictates the percolating inter-molecular network and viscoelastic properties of ageing condensates

S. Blazquez, I. Sanchez-Burgos, J. Ramirez, T. Higginbotham, M. M. Conde, R. Collepardo-Guevara, A. R. Tejedor, J. R. Espinosa

This study shows that the location and number of LARKS in proteins affect the viscoelastic properties and aging of biomolecular condensates, with multiple LARKS leading to gel-like behavior.

bioRxiv · Dec 14, 2022Biophysics

Time-dependent material properties of ageing biomolecular condensates from different viscoelasticity measurements in molecular dynamics simulations

A. R. Tejedor, R. Collepardo-Guevara, J. Ramirez, J. R. Espinosa

This study compares computational methods to measure viscoelasticity of biomolecular condensates in simulations, finding that SSRMI and OS techniques outperform BT in efficiency and accuracy.

bioRxiv · Dec 7, 2022 · PreprintBiophysics

Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it

A. R. Tejedor, I. Sanchez-Burgos, M. Estevez-Espinosa, A. Garaizar, R. Collepardo-Guevara, J. Ramirez, J. R. Espinosa

The paper shows that inter-protein β-sheets increase RNA-binding protein condensate viscosity and alter network connectivity, leading to gelation, but RNA can slow this process.

bioRxiv · Mar 30, 2022Biophysics

Dual RNA modulation of protein mobility and stability within phase-separated condensates

A. R. Tejedor, A. Garaizar, J. Ramirez, J. R. Espinosa

This study uses a coarse-grained model to show RNA modulates phase-separated condensate stability and transport properties through dual mechanisms depending on RNA concentration and length.

bioRxiv · Mar 5, 2021Biophysics