Author

I. Sanchez-Burgos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 6 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 4 Research Focus:chromatin & epigenetic regulation· 3 Approach:simulation· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

R. Collepardo-Guevara· 7 shared J. R. Espinosa· 6 shared A. R. Tejedor· 3 shared J. A. Joseph· 3 shared A. Garaizar· 2 shared J. Ramirez· 2 shared B. P. O'Hara· 1 shared C. Chauvet· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

7 shared papersBiophysics

R. Collepardo-Guevara

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Mechano-dependent sorbitol accumulation supports biomolecular condensate

S. Torrino, W. Oldham, A. R. Tejedor, I. Sanchez-Burgos, N. Rachedi, K. Fraissard, C. Chauvet, C. Sbai, B. P. O'Hara, S. Abelanet, F. Brau, S. Clavel, R. Collepardo-Guevara, J. Rene Espinosa, I. ben-sahra, T. BERTERO

The paper shows matrix stiffening promotes biomolecular condensation via sorbitol, a mechanosensitive metabolite, and demonstrates this in breast cancer.

bioRxiv · Jul 24, 2023Cell Biology

Location and concentration of aromatic-rich segments dictates the percolating inter-molecular network and viscoelastic properties of ageing condensates

S. Blazquez, I. Sanchez-Burgos, J. Ramirez, T. Higginbotham, M. M. Conde, R. Collepardo-Guevara, A. R. Tejedor, J. R. Espinosa

This study shows that the location and number of LARKS in proteins affect the viscoelastic properties and aging of biomolecular condensates, with multiple LARKS leading to gel-like behavior.

bioRxiv · Dec 14, 2022Biophysics

Surfactants or scaffolds? RNAs of different lengths exhibit heterogeneous distributions and play diverse roles in RNA-protein condensates

I. Sanchez-Burgos, L. Herriott, R. Collepardo-Guevara, J. R. Espinosa

This study uses simulations to show how RNA length and concentration affect RNA-protein condensate stability through distinct mechanisms involving surfactant-like and core-saturation roles of different RNA lengths.

bioRxiv · Nov 9, 2022Biophysics

Protein structural transitions critically transform the network connectivity and viscoelasticity of RNA-binding protein condensates but RNA can prevent it

A. R. Tejedor, I. Sanchez-Burgos, M. Estevez-Espinosa, A. Garaizar, R. Collepardo-Guevara, J. Ramirez, J. R. Espinosa

The paper shows that inter-protein β-sheets increase RNA-binding protein condensate viscosity and alter network connectivity, leading to gelation, but RNA can slow this process.

bioRxiv · Mar 30, 2022Biophysics

RNA length has a non-trivial effect in the stability of biomolecular condensates formed by RNA-binding proteins

I. Sanchez-Burgos, J. R. Espinosa, J. A. Joseph, R. Collepardo-Guevara

This study investigates how RNA length affects the stability of RNA-binding protein condensates through computational simulations of homotypic and heterotypic interactions.

bioRxiv · Oct 7, 2021Biophysics

Size conservation emerges spontaneously in biomolecular condensates formed by scaffolds and surfactant clients

I. Sanchez-Burgos, J. A. Joseph, R. Collepardo-Guevara, J. R. Espinosa

The paper shows that size-conserved biomolecular condensates can form spontaneously through phase separation of scaffolds and surfactant clients, depending on their concentration ratios.

bioRxiv · Apr 30, 2021Biophysics

Oligonucleotides can act as superscaffolds that enhance liquid-liquid phase separation of intracellular mixtures

J. A. Joseph, J. R. Espinosa, I. Sanchez-Burgos, A. Garaizar, D. Frenkel, R. Collepardo-Guevara

This study shows oligonucleotides enhance liquid-liquid phase separation by acting as superscaffolds, increasing molecular connectivity and reducing barriers for phase separation in protein-oligonucleotide mixtures.

bioRxiv · Jan 24, 2020Biophysics