Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis
E. Gabande-Rodriguez, G. Soto-Heredero, E. Carrasco, C. Anerillas, J. I. Escrig-Larena, S. Delgado-Pulido, I. Francos-Quijorna, M. M. Gomez de las Heras, A. Fernandez-Almeida, E. M. Blanco, E. Winand-Osete, V. Zorita, J. Martinez-Cano, A. Garrido, R. de Cabo, , M. Mittelbrunn
This study identifies CD4+ cytotoxic T cells in the bone marrow that enhance granulopoiesis in aged mice, contributing to age-related diseases and showing that CCR5 inhibition can mitigate these effects.
bioRxiv · Jan 26, 2024 · PreprintImmunology