Author

R. de Cabo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Biophysics· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

A. Garrido· 2 shared C. Anerillas· 2 shared M. Gorospe· 2 shared A. A. Teklu· 1 shared A. B. Herman· 1 shared A. Fernandez-Almeida· 1 shared B. Fink· 1 shared B. Nuss· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersImmunology

A. Garrido

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cytotoxic CD4+ T cells in the bone marrow compromise healthy ageing by enhancing granulopoiesis

E. Gabande-Rodriguez, G. Soto-Heredero, E. Carrasco, C. Anerillas, J. I. Escrig-Larena, S. Delgado-Pulido, I. Francos-Quijorna, M. M. Gomez de las Heras, A. Fernandez-Almeida, E. M. Blanco, E. Winand-Osete, V. Zorita, J. Martinez-Cano, A. Garrido, R. de Cabo, , M. Mittelbrunn

This study identifies CD4+ cytotoxic T cells in the bone marrow that enhance granulopoiesis in aged mice, contributing to age-related diseases and showing that CCR5 inhibition can mitigate these effects.

bioRxiv · Jan 26, 2024 · PreprintImmunology

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stress

C. Anerillas, K. Mazan-Mamczarz, A. B. Herman, R. Munk, G. K. Lam, M. Calvo-Rubio, A. Garrido, D. Tsitsipatis, J. L. Martindale, G. Altes, M. Rossi, Y. Piao, J. Fan, C.-Y. Cui, S. De, , M. Gorospe

This study identifies the YAP-TEAD pathway as a target for senolytic therapy, showing that inhibiting it induces apoptosis in senescent cells by increasing ER stress.

bioRxiv · Dec 18, 2022 · PreprintCell Biology

Cyb5r3-based mechanism and reversal of secondary failure to sulfonylurea

H. Watanabe, W. Du, J. Son, L. Sui, S.-i. Asahara, I. J. Kurland, T. Kuo, T. Kitamoto, Y. Miyachi, R. de Cabo, D. Accili

This study identifies Cyb5r3 downregulation as a mechanism of sulfonylurea failure and shows that a Cyb5r3 activator can reverse this failure in an animal model.

bioRxiv · Mar 23, 2022 · PreprintPhysiology

Ketones facilitate transcriptional resolution of secondary DNA structures in premature aging

M. A. Petr, L. M. Carmona-Marin, T. Tulika, S. Kristensen, S. Reves, D. Bakula, G. Keijzers, B. Osborne, S. J. Mitchell, S. Hamilton, J. Kato, I. Alfaras, A. A. Teklu, I. Heckenbach, J. Madsen, , M. Scheibye-Knudsen

This study shows that ketones like beta-hydroxybutyrate reduce premature aging features in Cockayne syndrome models by enhancing transcriptional readthrough of DNA secondary structures through histone acetylation.

bioRxiv · Mar 8, 2022 · PreprintPhysiology

ATP synthase K+- and H+-flux drive ATP synthesis and enable mitochondrial K+-uniporter function

M. Juhaszova, E. Kobrinsky, D. B. Zorov, B. Nuss, Y. Yaniv, K. W. Fishbein, R. de Cabo, L. Montoliu, S. B. Gabelli, M. A. Aon, S. Cortassa, S. J. Sollott

The paper demonstrates that ATP synthase uses K+ and H+ flux to drive ATP synthesis and functions as a mitochondrial K+-uniporter and KATP-channel.

bioRxiv · Apr 22, 2019 · PreprintBiophysics