Obesity impairs therapeutic efficacy of mesenchymal stem cells by inhibiting cardiolipin-dependent mitophagy and intercellular mitochondrial transfer in mouse models of airway allergic inflammation
S. Sagar, M. I. Faizan, N. Chaudhary, A. Gheware, K. Sharma, I. Azmi, V. P. Singh, G. Kharya, U. Mabalirajan, A. Agrawal, T. Ahmad, S. S. Roy
This study shows that obesity impairs MSCs' ability to perform mitophagy and intercellular mitochondrial transfer, and that PQQ can restore these functions in obese-derived MSCs.
bioRxiv · Nov 27, 2021 · PreprintCell Biology