Experimental type 1 diabetes metabolically rejuvenates CD8+ T cells for improved control of tumor growth through an IGF1-IGF1R axis
A. Sarkar, S. Dhar, S. Bera, M. Chakravarti, A. Verma, P. Prasad, J. Sultana, J. Das, A. Saha, A. Bhuniya, I. Guha, S. Dasgupta, S. S. Roy, S. Banerjee, S. Roy, , A. Bose
This study shows that experimental type 1 diabetes enhances CD8+ T cell function via the IGF1-IGF1R axis, leading to better tumor control.
bioRxiv · Apr 4, 2024 · PreprintCancer Biology