N. Chaudhary

Patterns of physical activity in hunter-gatherer children compared with US and UK children.

This study compares physical activity levels in BaYaka hunter-gatherer children with US and UK children, finding higher activity in BaYaka children and age-related differences.

Alpha-synuclein expression in neuron modulates the Japanese encephalitis virus infection

This study investigates how alpha-synuclein expression in neurons affects Japanese encephalitis virus infection, finding that it reduces viral replication by modulating oxidative stress through SOD1.

EGFR-to-Src family tyrosine kinase switching in proliferating-DTP TNBC cells creates a hyperphosphorylation-dependent vulnerability to EGFR TKI

This study identifies a hyper-phosphorylation state in drug-resistant TNBC cells caused by EGFR-to-Src kinase switching, making them vulnerable to EGFR TKI treatment.

GPX4-VIM equates a proliferating DTP state in TNBC subtypes with converged vulnerabilities to autophagy and glutathione inhibition.

The paper identifies a proliferating DTP state in TNBC subtypes that is vulnerable to autophagy and glutathione inhibition, linking GPX4-VIM expression to survival outcomes.

Lipid nanoparticle structure and delivery route during pregnancy dictates mRNA potency, immunogenicity, and health in the mother and offspring

This study identifies LNP structures that deliver mRNA effectively and safely during pregnancy, showing how their composition affects immunogenicity, maternal organ expression, and offspring health.

Hunter-gatherer oral microbiomes are shaped by contact network structure

This study examines how social network structure influences the oral microbiome of Agta hunter-gatherers, finding that social interactions significantly shape bacterial transmission.

Obesity impairs therapeutic efficacy of mesenchymal stem cells by inhibiting cardiolipin-dependent mitophagy and intercellular mitochondrial transfer in mouse models of airway allergic inflammation

This study shows that obesity impairs MSCs' ability to perform mitophagy and intercellular mitochondrial transfer, and that PQQ can restore these functions in obese-derived MSCs.

Bitter taste perception in BaYaka hunter-gatherers

The paper examines bitter taste perception variation within the Mbendjele BaYaka hunter-gatherers, finding that town-raised individuals are more sensitive to bitter tastes than forest-raised individuals.

Profiling of mature stage human breastmilk cells identifies host-defense lactocyte sub-populations

The paper identifies host-defense lactocyte sub-populations in mature human breastmilk using multi-omics approaches.

CCNE1 amplification is synthetic-lethal with PKMYT1 kinase inhibition

The paper identifies PKMYT1 as a therapeutic target for CCNE1-amplified cancers, showing that its inhibition leads to synthetic lethality and tumor regression in combination with gemcitabine.

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

This study shows that Cavin1's intrinsically disordered domains are essential for caveola formation and trafficking through electrostatic interactions and phase separation.

CIP2A is a prime synthetic-lethal target for BRCA-mutated cancers

The paper identifies CIP2A as a synthetic-lethal target in BRCA-mutated cancers by showing its essential role in mitotic chromosome stability and its interaction with TOPBP1.

Insulin promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10.

The paper shows insulin mobilizes GLUT4 from a TGN storage site via RAB10, revealing a non-specific TGN region for cargo transport.

From Farm to Pharmacy: Strawberry-Enabled Oral Delivery of Protein Drugs

This study identifies strawberry-derived pelargonidin as a safe and effective permeability enhancer for oral delivery of protein drugs in mice.

Mechanochemical feedback and control of endocytosis and membrane tension

The paper identifies a negative feedback loop between membrane tension and the CLIC/GEEC pathway mediated by vinculin and GBF1.