Membrane cholesterol regulates TRPV4 function, cytoskeletal expression and the cellular response to tension
M. Lakk, G. E. Hoffmann, A. Gorusupudi, E. Enyong, P. Bernstein, T. L. Toft-Bertelsen, N. MacAulay, M. H. Elliott, D. Krizaj
This study shows that membrane cholesterol modulates TRPV4 channel activity, cytoskeletal changes, and cellular response to mechanical strain in human trabecular meshwork cells.
bioRxiv · Dec 1, 2020Cell Biology