Author

M. Lakk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Assay:electrophysiology· 4 Organism:human· 4 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. Krizaj· 5 shared C. N. Rudzitis· 3 shared O. Yarishkin· 3 shared F. Vazquez-Chona· 2 shared J. M. Baumann· 2 shared A. Gorusupudi· 1 shared C. Sundberg· 1 shared D. Overby· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersCell Biology

D. Krizaj

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Osmosensing in trabecular meshwork cells

J. M. Baumann, O. Yarishkin, M. Lakk, C. N. Rudzitis, Y.-T. Tseng, D. Krizaj

This study investigates osmosensing mechanisms in trabecular meshwork cells, identifying TRPV4 and Cl- channels as key players in volume regulation and calcium homeostasis under osmotic stress.

bioRxiv · Apr 3, 2024 · PreprintPhysiology

TRPM4 is required for calcium oscillations downstream from the stretch-activated TRPV4 channel

O. Yarishkin, T. T. Phuong, F. Vazquez-Chona, J. A. Bertrand, S. Redmon, M. Lakk, J. M. Baumann`, C. N. Rudzitis, E. M. Hwang, D. Overby, D. Krizaj

The paper shows TRPM4 is required for calcium oscillations downstream from TRPV4 in trabecular meshwork cells, linking mechanical stretch to intracellular signaling.

bioRxiv · Dec 15, 2021 · PreprintCell Biology

Membrane cholesterol regulates TRPV4 function, cytoskeletal expression and the cellular response to tension

M. Lakk, G. E. Hoffmann, A. Gorusupudi, E. Enyong, P. Bernstein, T. L. Toft-Bertelsen, N. MacAulay, M. H. Elliott, D. Krizaj

This study shows that membrane cholesterol modulates TRPV4 channel activity, cytoskeletal changes, and cellular response to mechanical strain in human trabecular meshwork cells.

bioRxiv · Dec 1, 2020Cell Biology

Mechanically induced cytoskeletal remodeling in trabecular meshwork cells requires TRPV4 - Rho signaling interactions

M. Lakk, D. Krizaj

This study shows that TRPV4 and ROCK signaling are required for mechanical stress-induced cytoskeletal remodeling in trabecular meshwork cells.

bioRxiv · Aug 11, 2020 · PreprintCell Biology

Mechanotransduction and dynamic outflow regulation in trabecular meshwork requires Piezo1 channels

O. Yarishkin, T. T. T. Phuong, J. M. Baumann, M. L. De Ieso, F. Vazquez-Chona, C. N. Rudzitis, C. Sundberg, M. Lakk, W. D. Stamer, D. Krizaj

This study identifies Piezo1 channels as critical for mechanosensitivity in trabecular meshwork cells, showing their role in pressure response, calcium signaling, and outflow regulation.

bioRxiv · Jun 30, 2020 · PreprintPhysiology