Filling of a water-free void explains the allosteric regulation of the β1-adrenergic receptor by cholesterol
L. A. Abiko, R. Dias Teixeira, S. Engilberge, A. Grahl, S. Grzesiek
The paper identifies dry voids in the β1-adrenergic receptor that cholesterol fills, explaining its allosteric regulation and suggesting new drug development strategies.
bioRxiv · Aug 30, 2021Biophysics