Author

O. Hartley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Furstenberg· 1 shared A. Grahl· 1 shared C. A. Rico· 1 shared C.-J. Tsai· 1 shared E. Lorenzen· 1 shared F. Pamula· 1 shared G. F. X. Schertler· 1 shared H. Gaertner· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiophysics

A. Furstenberg

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Structural basis of the activation of the CC chemokine receptor 5 by a chemokine agonist

P. Isaikina, C.-J. Tsai, N. B. Dietz, F. Pamula, A. Grahl, K. N. Goldie, R. Guixa-Gonzalez, G. F. X. Schertler, O. Hartley, H. Stahlberg, T. Maier, X. Deupi, S. Grzesiek

The paper reports the cryo-EM structure of CCR5 bound to a chemokine agonist and Gi protein, revealing its activation mechanism.

bioRxiv · Nov 27, 2020Biophysics

High-Affinity Binding of Chemokine Analogs that Display Ligand Bias at the HIV-1 Co-receptor CCR5

C. A. Rico, Y. A. Berchiche, M. Horioka, J. C. Peeler, E. Lorenzen, H. Tian, M. A. Kazmi, A. Furstenberg, H. Gaertner, O. Hartley, T. P. Sakmar, T. Huber

The paper develops a fluorescence assay to study high-affinity chemokine analogs that show ligand bias at CCR5, finding they bind with subnanomolar affinities and occupy a site not accessible to native chemokines.

bioRxiv · Mar 16, 2019Biophysics