Author

A. Gruszczynska

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. Heard· 1 shared A. Kumar· 1 shared C. R. York· 1 shared D. DeNardo· 1 shared D. H. Spencer· 1 shared F. Ferraro· 1 shared G. Hogg· 1 shared H. Ha· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. Heard

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesis

N. Arthur, K. A. Christensen, K. Mannino, M. Ruzinova, A. Kumar, A. Gruszczynska, R. B. Day, P. Erdmann-Gilmore, Y. Mi, R. Sprung, C. R. York, D. H. Spencer, R. Townsend, S. M. Sykes, F. Ferraro

This study shows that MBI MYC mutations alter MYC localization and disrupt mRNA subcellular distribution and turnover, promoting leukemogenesis.

bioRxiv · Oct 22, 2023 · PreprintCancer Biology

Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction

M. E. Selli, J. H. Landmann, M. Terekhova, J. Lattin, A. Heard, Y.-S. Hsu, T.-C. Chang, J. M. Warrington, H. Ha, N. Kingston, G. Hogg, M. Slade, M. M. Berrien-Elliot, M. Foster, S. Kersting-Schadek, , N. Singh

This study identifies that chronic activation of 41BB-based CARs leads to a novel T cell dysfunction state, distinct from exhaustion, which can be mitigated by disrupting FOXO3.

bioRxiv · Jan 26, 2023 · PreprintImmunology