Author

M. Ruzinova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

A. B. A. Laranjeira· 1 shared A. Gruszczynska· 1 shared A. Kumar· 1 shared A. Z. Wang· 1 shared C. R. York· 1 shared D. Fisher· 1 shared D. H. Spencer· 1 shared F. Ferraro· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

A. B. A. Laranjeira

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2 papers

Recent·Most cited

Missense mutations in Myc Box I influence MYC cellular localization, mRNA partitioning and turnover to promote leukemogenesis

N. Arthur, K. A. Christensen, K. Mannino, M. Ruzinova, A. Kumar, A. Gruszczynska, R. B. Day, P. Erdmann-Gilmore, Y. Mi, R. Sprung, C. R. York, D. H. Spencer, R. Townsend, S. M. Sykes, F. Ferraro

This study shows that MBI MYC mutations alter MYC localization and disrupt mRNA subcellular distribution and turnover, promoting leukemogenesis.

bioRxiv · Oct 22, 2023 · PreprintCancer Biology

DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression

T. Kong, A. B. A. Laranjeira, K. Yang, D. Fisher, L. Yu, A. Z. Wang, M. Ruzinova, J. Fowles, M. Allen, H. Celik, G. Challen, S. Huang, S. Oh

This study identifies DUSP6 as a driver of leukemic progression and resistance to JAK2 inhibition in MPNs, highlighting the DUSP6-RSK1 axis as a therapeutic target.

Nature Cancer · Dec 29, 2022Peer-reviewedCancer Biology