Bariatric surgery reveals a gut-restricted TGR5 agonist that exhibits anti-diabetic effects
S. N. Chaudhari, D. A. Harris, H. Aliakbarian, M. T. Henke, R. Subramaniam, A. H. Vernon, A. Tavakkoli, E. G. Sheu, A. S. Devlin
This study identifies CA7S, a gut-restricted TGR5 agonist that improves glucose tolerance in insulin-resistant mice by inducing GLP-1 secretion.
bioRxiv · Jan 10, 2020Biochemistry