Peripheral macrophages causally contribute to disease onset and progression in the Ndufs4(KO) model of Leigh syndrome
A. Hanaford, A. Khanna, K. James, Y. Chen, M. Mulholland, B. Kayser, V. Truong, M. M. Sedensky, P. G. Morgan, V. Kalia, S. Sarkar, S. C. Johnson
This study shows that peripheral macrophages contribute to CNS lesions in the Ndufs4(-/-) Leigh syndrome model, despite microglia depletion having limited effect.
bioRxiv · Jan 27, 2023 · PreprintPathology