S. C. Johnson

IFNγ modestly contributes to disease progression in the Ndufs4(-/-) model of Leigh syndrome while IP10 is dispensable

Peripheral macrophages causally contribute to disease onset and progression in the Ndufs4(KO) model of Leigh syndrome

This study shows that peripheral macrophages contribute to CNS lesions in the Ndufs4(-/-) Leigh syndrome model, despite microglia depletion having limited effect.

Genetic, Clinical Underpinnings of Brain Change Along Two Neuroanatomical Dimensions of Clinically-defined Alzheimer's Disease

This study identifies two brain atrophy dimensions in Alzheimer's disease using Surreal-GAN and links them to genetic and clinical factors, revealing distinct pathological mechanisms.

Inducing Specific Chromosome Mis-Segregation in Human Cells

This study induces specific chromosome mis-segregation in human cells using CRISPR-Cas9 to create designer karyotypes and study aneuploidy's cellular effects.

Leukocyte proliferation mediates disease pathogenesis in the Ndufs4(KO) mouse model of Leigh syndrome

The paper shows that leukocyte proliferation drives Leigh syndrome pathology in Ndufs4(KO) mice, and leukocyte depletion prevents CNS lesions and extends survival.

Mechanisms underlying neonate specific metabolic effects of volatile anesthetics

This study identifies a neonate-specific metabolic effect of volatile anesthetics, showing they deplete beta-hydroxybutarate at sub-anesthetic concentrations, mediated by citrate and malonyl-CoA changes, which adults are less sensitive to.

Lymph node swelling combined with temporary effector T cell retention aids T cell response in a model of adaptive immunity

The paper models lymph node swelling's impact on T cell response, finding that temporary retention of effector T cells can counteract negative effects of swelling on immune response.

Inflammatory state of lymphatic vessels and miRNA profiles associated with relapse in ovarian cancer patients