Linker histone H1-0 is a specific mediator of the repressive ETV6::RUNX1 transcriptional landscape
V. H. Jepsen, A. Hanel, D. Picard, J. Mehtonen, R. Hasselmann, J. Schliehe-Diecks, K. Scharov, J.-W. Tu, R. Bhave, E. Kameri, N. Qin, H. Wang, Z. Zhuang, R. Wagener, L. Blümel, , U. Fischer
This study identifies H1-0 as a mediator of ETV6::RUNX1-induced quiescence in BCP-ALL preleukemic cells and suggests HDACi treatment as a potential therapeutic approach.
bioRxiv · Jun 28, 2024Cancer Biology